A cytosine·cytosine base paired parallel DNA double helix with thymine·thymine bulges
- 15 September 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 205 (2) , 223-229
- https://doi.org/10.1016/0014-5793(86)80902-4
Abstract
500 MHz 1H NMR studies using 2D-NOESY indicate that the oligonucleotide d(CTCTCT) at low pH forms a parallel double helix with cytosine·cytosine base pairs and thymine·thymine bulges. This unusual structure may explain the hypersensitivity of S1 nuclease at low pH towards supercoiled plasmids containing d(CT) n inserts.Keywords
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