Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta
- 1 July 1987
- journal article
- research article
- Published by Springer Nature in Skeletal Radiology
- Vol. 16 (5) , 360-363
- https://doi.org/10.1007/bf00350961
Abstract
A 12-year-old female suffering fromosteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.This publication has 11 references indexed in Scilit:
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