EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-3 IN APLASTIC-ANEMIA
- 1 October 1990
- journal article
- research article
- Vol. 76 (7) , 1287-1292
Abstract
In a phase I/II study, nine patients with aplastic anemia were treated with recombinant human interleukin-3 (rhIL-3) to assess the toxicity and biologic effects of this multipotential hematopoietic growth factor. Doses ranging from 250 .mu.g/m2 to 500 .mu.g/m2 were administered as subcutaneous bolus injections daily for 15 days. An increase in platelet counts from 1,000/.mu.L to 31,000/.mu.L was induced by rhIL-3 in one patient, and an increase in reticulocyte counts by more than 10,000/.mu.L in four patients. The blood leukocyte counts temporarily increased in eight patients 1.5- to 3.3-fold (median, 1.8-fold), mainly due to an increase in the number of neutrophils, eosinophils, lymphocytes, and monocytes. In two patients, bone marrow cellularity increased from 7% to 33% and from 10% to 80%, respectively, but without resulting in a substantial improvement of peripheral blood counts. Mild side effects (headache and flushing) were observed in some patients, while low-grade fever occurred in all patients. Transient thrombocytopenia necessitating discontinuation of rhIL-3 treatment occurred in one patient. In conclusion, rhIL-3 can stimulate hematopoiesis in patients with aplastic anemia; however, no lasting effects were obtained.This publication has 5 references indexed in Scilit:
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