Changes in glucagon levels after four to five weeks of glucoregulation by portable insulin infusion pumps
- 1 November 1979
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 28 (11) , 1033-1035
- https://doi.org/10.2337/diabetes.28.11.1033
Abstract
Near-normal glucoregulation was maintained in five patients with juvenile-onset diabetes mellitus for 4–5 wk with a preprogrammed, continuous, subcutaneous insulin infusion using a portable battery-powered infusion pump. This form of therapy significantly lowered immunoreactive glucagon (IRG) levels below those observed while on conventional insulin treatment at several times during the 24-h profile. The maximum IRG levels were also reduced in all five subjects. Thus, a flexible system of insulin delivery, as is provided by certain open-loop pump systems, can overcome inappropriate glucagon secretion that occurs with conventional insulin therapy.This publication has 3 references indexed in Scilit:
- Long-term continuous intravenous insulin therapy with a portable insulin dosage-regulating apparatusDiabetes, 1979
- Effect of Insulin Therapy on the Profiles of Plasma Immunoreactive Glucagon in Juvenile-type and Adult-type DiabeticsDiabetes, 1978
- Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes mellitusDiabetes, 1976