Studies of Herpes Simplex Virus by the Gel Diffusion Technique

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Abstract
Summary: Herpes simplex virus obtained from infected rabbit kidney cell tissue cultures contained high titers of precipitating antigens, which proved suitable for use in a diagnostic test for precipitins in primary and recurrent herpes infections. The use of this test in the screening of the sera of 671 persons has provided valuable information regarding human precipitins, particularly with respect to the existence of wide variations in the antigen-antibody systems involved. The precipitin tests used in these studies should be of value for the detection of infections in patients with passively acquired circulating antibodies. A high incidence of primary and recurrent herpes simplex virus infections of the upper respiratory tract were observed in the present study.

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