In-vitro activity of ceftazidime compared with other -lactam antibiotics
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 8 (suppl B) , 57-62
- https://doi.org/10.1093/jac/8.suppl_b.57
Abstract
Ceftazidime and ceftriaxone (Ro 13–9904), two new parenteral cephalosporins, were compared with other β-lactam antibiotics against a total of 237 recent clinical isolates. Both ceftazidime and ceftriaxone had good activity against the Enterobacteriaceae, with 90% of isolates being inhibited by 0.5 mg/l of ceftazidime and by 0.25 mg/l of ceftriaxone. Against Pseudomonas aeruginosa , ceftazidime was about four times more active than ceftriaxone which, in turn, was at least eight times more active than carbenicillin. Both ceftazidime and ceftriaxone were highly active against β-lactamase producing and non-β-lactamase producing Haemophilus influenzae . Against the Bacteroides fragilis group, neither ceftazidime nor ceftriaxone showed good activity, the MIC 90 for ceftazidime being > 128mg/l and the MIC 90 for ceftriaxone being 32mg/l. Both ceftazidime and ceftriaxone were less active than cephalothin against Staphylococcus aureus .Keywords
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