Experimental Intravaginal Infection with Trichomonas foetus in Guinea Pigs

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Abstract
An experimental T. foetus vaginal infection can be established in female guinea pigs receiving a supporting treatment of estradiol undecylate and triamcinolone acetonide. T. foetus can be isolated from the vagina of about 95% of the animals for at least 5 weeks. Infected animals did not exhibit abnormal clinical signs nor gross or histopathological lesions. Addition of amphotericin B to a semi-solid culture medium containing penicillin and streptomycin improves isolation of Trichomonas by minimizing contamination of isolates by yeast-like organisms. Oral treatment with 2-methyl-5-nitro-imidazole-1-ethanol (metronidazole), at levels recommended for human use, cures the infection. In addition, the infection can be treated by intravaginal application of other anti-trichomonal agents.