Resistance of Aeromonas hydrophila to β-lactam antibiotics

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Abstract
The activity of some β-lactam antibiotics upon 20 strains of Aeromonas hydrophila and some properties of their β-lactamases have been studied. High degree of resistance to benzylpenicillin and lower resistance to ampicillin and cephaloridine was observed. Clavulanic acid showed the highest activity. When clavulanic acid was assayed at subinhibitory concentrations in association with ampicillin. MICs of the latter decreased to two- to eight-fold. All strains produced inducible β-lactamases with high activity upon ampicillin. A group of cephalosporinase-like enzymes was also found. Some β-lactamases were inhibited by cloxacillin, and most of them were completely inhibited by 5 mg/1 of clavulanic acid. Low impermeability of Aerom. hydrophila cells to β-lactams was observed.