Relationship of Ketone Body Metabolism and Carbohydrate Utilization to Fat Mobilization in the Ruminant

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Abstract
A significant decrease in plasma nonesterified fatty acid (NEFA) level occurred during intravenous administration of sodium [beta]-hydroxybutyrate to goats previously fasted or fasted and phlorizinized. No significant change in plasma glucose concentration was observed during the infusion in either metabolic state. A depression in plasma NEFA level of lower magnitude was also noted during infusion of [beta]-hydroxybutyrate to alloxan-diabetic goats. A direct feedback effect of ketone bodies on fat mobilization is implicated, although the presence of insulin may be necessary for maximum suppression of NEFA release.