Tumor Gene Expression and Interphase Chromatin Appearance inXiphophorus

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Abstract
SYNOPSIS. Xiphophorus maculatus (platyfish) exhibits spots which consist of neoplastically transformed pigment cells (T-cells). The spots actually represent extreme benign melanomas. Transformation to T-cells is mediated by a “tumor gene” (Tu). Platyfish which develop from X-irradiated embryos reveal an increase of Tu-expression resulting in an overproduction of T-cells to benign melanomas which can be compared to that observed in certain hybrids between the platyfish and Xiphophorus helleri (swordtail). Both the X irradiation-induced and the crossing conditioned increase of Tu-expression represent a heritable alteration which might be related to a conversion from dispersed to condensed chromatin in the interphase nuclei.

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