New synthesis of (+)-and (–)-nojirimycin from myo-inositol
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1230-1231
- https://doi.org/10.1039/c39890001230
Abstract
A report of a new synthesis of nojirimycin (1a), as well as its antipode (1b), from optically active seven-membered hemiacetal lactones (2a,b) derived from myo-inositol by a five step reaction; the hydrogen sulphite adduct of (1b) shows high inhibitory activity against β-glucosidase and α-mannosidase, being almost comparable to that of mannojirimycin.Keywords
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