COMBINATION OF HIGH-DOSE CYCLOPHOSPHAMIDE, BCNU, AND VP-16-213 FOLLOWED BY AUTOLOGOUS MARROW RESCUE IN THE TREATMENT OF RELAPSED LEUKEMIA
- 1 January 1981
- journal article
- research article
- Vol. 65 (5-6) , 377-381
Abstract
The combination of high-dose cyclophosphamide, BCNU [1,3-bis-(2-chloroethyl)-1-nitrosourea] and VP 16-213 followed by autologous marrow rescue was evaluated in the treatment of relapsed leukemia refractory to normal-dose chemotherapy. Cyclophosphamide was given at a total dose of 4.5 g/m2, BCNU at a dose of 300 mg/m2 and VP 16-213 at a dose of 600 mg/m2. Seven high-dose treatments followed by marrow rescue were administered to 6 patients. Two patients achieved complete remissions, 3 had partial remissions, and 1 achieved a minimal response. The toxicity of this regimen was moderate.This publication has 4 references indexed in Scilit:
- High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumorsCancer, 1980
- AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN RELAPSED ADULT ACUTE LEUKÆMIAThe Lancet, 1979
- TREATMENT OF BLASTIC TRANSFORMATION OF CHRONIC GRANULOCYTIC LEUKEMIA BY CHEMOTHERAPY, TOTAL-BODY IRRADIATION AND INFUSION OF CRYOPRESERVED AUTOLOGOUS MARROW1978
- SUCCESSFUL ENGRAFTMENT OF CRYOPRESERVED AUTOLOGOUS BONE-MARROW IN PATIENTS WITH MALIGNANT-LYMPHOMA1978