COMPARATIVE-STUDY OF PARENTERAL PIPERACILLIN AND CEFOXITIN IN THE TREATMENT OF SURGICAL INFECTIONS OF THE ABDOMEN

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 157  (5) , 423-425
Abstract
Patients who had contaminated traumatic perforations of the gastrointestinal tract or acute peritonitis resulting from acute surgical inflammatory conditions were treated with piperacillin or cefoxitin infused i.v. as single therapy for a minimum of 5 days. Patients (34) were given 4.5 g of piperacillin every 6 h and 26 patients, 2.0 g of cefoxitin every 6 h. In the piperacillin group, 63 organisms (34 aerobes and 29 anaerobes) were isolated from pretreatment cultures; in the cefoxitin group, 73 organisms (35 aerobes and 38 anaerobes) were isolated. Clinical recovery was achieved in 31 of 34 patients receiving piperacillin therapy and in 24 of 26 patients receiving cefoxitin therapy. Organisms were resistant to the respective drug in 2 piperacillin-treated patients and in 1 cefoxitin-treated patient; the patients were given other antibacterial treatment. One patient from each treatment group died of causes unrelated to septic conditions. No serious adverse effects occurred from either antibiotic.