ANTI-TUMOR ACTIVITY OF PERITONEAL EXUDATE CELLS INDUCED BY CELL-WALL SKELETON OF MYCOBACTERIUM-BOVIS BCG
- 1 January 1978
- journal article
- research article
- Vol. 69 (6) , 831-834
Abstract
Peritoneal exudate cells (PEC) induced by oil-attached cell-wall skeleton of M. bovis BCG (BCG-CWS) in ACI/N rats were tested for their effect on both in vivo and in vitro growth of syngeneic [rats] fibrosarcoma cells (AMC-60). Treatment of rats with i.p. injections of BCG-CWS induced regression of syngeneic ascites tumor and increased the number of survivals. Whole PEC and adherent PEC from rats injected i.p. with BCG-CWS inhibited the uptake of tritiated thymidine into the fibrosarcoma cells in an in vitro cytostasis test. This in vitro cytostatic effect was more marked as the ratio of effector to target cells increased. In addition, when tumor cells were inoculated s.c. with BCG-CWS activated PEC, tumor takes decreased markedly. Oil-stimulated PEC and normal peritoneal resident cells were inactive in inhibition of tumor growth in vivo and in vitro.This publication has 6 references indexed in Scilit:
- Adjuvant activity of synthetic N-acetylmuramyl-l-alanyl-d-isoglutamine and related compounds on cell-mediated cytotoxicity in syngeneic miceCellular Immunology, 1977
- EXPERIMENTAL IMMUNOTHERAPY OF NEOPLASTIC PLEURAL EFFUSION WITH OIL-ATTACHED BCG CELL-WALL SKELETON IN MICE1976
- IMMUNOTHERAPY OF HUMAN LUNG-CANCER WITH BCG CELL-WALL SKELETON1976
- SUCCESSFUL TREATMENT OF PATIENTS WITH MALIGNANT PLEURAL EFFUSION WITH BCG CELL-WALL SKELETON1976
- ACTIVATED MACROPHAGES AS CYTOTOXIC EFFECTOR CELLSTransplantation, 1975
- IMMUNE MECHANISMS IN HOMOTRANSPLANTATION .2. QUANTITATIVE ASSAY OF IMMUNOLOGIC ACTIVITY OF LYMPHOID CELLS STIMULATED BY TUMOR HOMOGRAFTS1961