Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat

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Abstract
Rats were administered toloxatone 100 mg kg−1 p.o., and killed 0·5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by toloxatone.