Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni , Fasciola hepatica , Clonorchis sinensis , and Opisthorchis viverrini
- 1 March 2007
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 51 (3) , 1096-1098
- https://doi.org/10.1128/aac.01366-06
Abstract
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.Keywords
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