INCORPORATION OF THYMIDINE-C-14 INTO LIVER AND BRAIN DNA OF PROTEIN-DEFICIENT RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 27  (1) , 69-73
Abstract
The effect of a protein-free diet on 14C-thymidine incorporation into rat liver DNA was studied in vivo, and, after 2-3 wk a marked decrease in uptake of the radioactive base into the liver DNA was noted, followed by a decrease in the proportion of DNA in liver cell homogenates. The total nuclear count/per miligram liver tissue displayed an increase during protein depletion, except for the 5th wk, when a decrease was recorded. The incorporation of 14C-thymidine into brain DNA likewise displayed no great differences, although a significant drop was observed during the 2nd-4th wk of depletion. In the 5th wk an increase in uptake of the radioactive base by brain DNA was recorded, exceeding the incorporation values in the controls.

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