Involvement of second messengers and protein phosphorylation in astrocyte swelling
- 15 May 1992
- journal article
- review article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 70 (S1) , S362-S366
- https://doi.org/10.1139/y92-284
Abstract
In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.Key words: astrocyte, Ca2+-dependent protein kinases, Ca2+ influx, cell volume, cyclic AMP, inositol phosphates, protein phosphorylation.Keywords
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