Targeting DNA topoisomerase II in cancer chemotherapy
Top Cited Papers
- 20 April 2009
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 9 (5) , 338-350
- https://doi.org/10.1038/nrc2607
Abstract
The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of TOP2 and an improved anticancer strategy? Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. Although the biological functions of TOP2 are important for ensuring genomic integrity, the ability to interfere with TOP2 and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. The molecular tools that have allowed an understanding of the biological functions of TOP2 are also being applied to understanding the details of drug action. These studies promise refined targeting of TOP2 as an effective anticancer strategy.This publication has 175 references indexed in Scilit:
- Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNAMolecular Cell, 2009
- The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in CellsBiochemistry, 2008
- A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapyInvestigational New Drugs, 2008
- Substituents on Etoposide That Interact with Human Topoisomerase IIα in the Binary Enzyme−Drug Complex: Contributions to Etoposide Binding and ActivityBiochemistry, 2008
- Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 ComplexMolecular Cell, 2007
- Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous RecombinationMolecular Cell, 2007
- Topoisomerase II−Drug Interaction Domains: Identification of Substituents on Etoposide That Interact with the EnzymeBiochemistry, 2007
- Repair of Topoisomerase I‐Mediated DNA DamageProgress in Nucleic Acid Research and Molecular Biology, 2006
- A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinBiochemical Pharmacology, 1999
- Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein FamilyCell, 1997