Runaway telomere elongation caused by telomerase RNA gene mutations
- 1 August 1995
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 376 (6539) , 403-409
- https://doi.org/10.1038/376403a0
Abstract
The ribonucleoprotein enzyme telomerase adds telomeric DNA onto chromosome ends and is normally regulated so that telomeric DNA lengths are kept within defined bounds. In the telomerase RNA gene from the yeast Kluyveromyces lactis, specific mutations that alter telomeric DNA sequences result in telomeres elongating to up to 100 times their normal length and impair cell growth. Some mutations cause immediate elongation whereas others behave like genetic time bombs, causing elongation only after a latent period of hundreds of generations.Keywords
This publication has 41 references indexed in Scilit:
- The ends and the middle: putting chromosomes togetherCurrent Opinion in Genetics & Development, 1994
- Telomeres: No end in sightCell, 1994
- An alternative pathway for yeast telomere maintenance rescues est1− senescencePublished by Elsevier ,1993
- Structure and function of telomeresNature, 1991
- RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stabilityCell, 1990
- Telomeres shorten during ageing of human fibroblastsNature, 1990
- Functional Evidence for an RNA Template in TelomeraseScience, 1990
- Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loopsNature, 1989
- STRUCTURE AND FUNCTION OF TELOMERESAnnual Review of Genetics, 1989
- Properties of the telomeric DNA-binding protein from Oxytricha novaBiochemistry, 1989