Mapping of the Human Gene for Inducible Heme Oxygenase to Chromosome 22ql2.

1 January 1994

journal article
Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine

Vol. 172 (4) , 389-392
https://doi.org/10.1620/tjem.172.389

Abstract

Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22q12.

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