Effect of a Novel Antiallergic Drug, Pemirolast, on Activation of Rat Peritoneal Mast Cells: Inhibition of Exocytotic Response and Membrane Phospholipid Turnover
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 96 (1) , 62-67
- https://doi.org/10.1159/000235536
Abstract
The effects of a potent antiallergic drug, pemirolast (TBX), on activation of signal-transducing phospholipase C and A2, were examined in rat peritoneal mast cells. TBX at concentrations between 10––7 and 10––5 g/ml effectively inhibited degranulation in response to both antigen and compound 48/80. At the same concentrations the drug markedly suppressed the formation of 1,2-diacylglycerol and phosphatidic acid, and the decrease in phosphatidylinositol, suggesting the prevention of phospholipase C activation. The blockade of phospholipase A2 was suggested by the decrease in agonists-induced arachidonic acid liberation. These results indicate that TBX may exert its inhibitory effects on mast cells, at least in part, by preventing the activation of signal-transducing phospholipases.Keywords
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