INTRAUTERINE GROWTH RETARDATION AND RISK OF SUDDEN INFANT DEATH SYNDROME (SIDS)

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Abstract
The purpose of this study was to assess whether intrauterine growth retardation was associated with an increased risk of sudden infant death syndrome (SIDS). A total of 148 SIDS cases were identified from the Upstate New York (exclusive of New York City) live birth cohort for 1974 (n = 132,948). Dead controls represented all other sudden deaths (n = 114). Live controls were randomly selected and matched to cases on mother's age, race, parity, and residence and infant's birth date (n = 355). Data were collected from vital certificates (response, 97%), medical records (89%), and autopsy reports (100%). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with the use of logistic regression techniques to control for confounding. With live controls, significant risks were observed for gestations <37 weeks (OR = 2.2, CI 1.2–4.1), birth weights 42 weeks) were at lowest risk (live controls OR = 0.9, CI 0.5–1.6; dead controls OR = 0.6, CI 0.3–1.1). When gestational age was controlled for, SIDS infants were found to have reductions in both weight and length; this suggests that responsible mechanisms begin early in pregnancy.

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