History.—On March 14, 1932, Mrs. E. B., aged 39, was admitted to the wards of the Presbyterian Hospital in the service of Dr. John H. Girvin, with the history that for the preceding two years there had been spells of vaginal bleeding lasting from three to fourteen days. The family history was irrelevant. The patient had had the usual diseases of childhood ; when 19 years of age, she had typhoid fever, and at the age of 21 she had an attack of pulmonary tuberculosis for which she was treated in the country for thirteen months. She had been married for twenty years, and had had one pregnancy ; the child died owing to placenta praevia. The last bleeding spell started fifteen days before admission, the bleeding at times being profuse, with no apparent reason. Examination.—Examination by Dr. Laws showed that the cervix was soft and widely dilated, with a