Regional Mitochondrial Respiratory Activity in Huntington's Disease Brain
- 1 June 1985
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 44 (6) , 1948-1950
- https://doi.org/10.1111/j.1471-4159.1985.tb07192.x
Abstract
This study investigated mitochondrial respiratory activity in Huntington's disease (HD) brain. Mitochondrial membranes from caudate and cortex of HD and non-HD autopsied brains were assayed for succinate oxidation, cytochrome oxidase activity, and cytochromes b, cc1, and aa3. There was a significant decrease in HD caudate mitochondrial respiration, cytochrome oxidase activity, and cytochrome aa3, whereas cytochromes b and cc1 were normal. These findings are consistent with the hypothesis that mitochondrial dysfunction may contribute to the localized hypometabolism and progressive atrophy of the HD caudate.Keywords
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