Plasminic Activity and Emotional Stress

Publisher Website
Google Scholar
Abstract
Hereditary angioneurotic edema (HANE) is clearer in the etiology than the other types of angioneurotic edema. It shows abnormal serum complemental activity and various clinical signs. It has been reported by many clinicians that the onset and the progress of this disease are frequently and deeply concerned with emotional stress. The two cases, showing that the symptoms of HANE occurred repeatedly in stressful situations were presented. To make the relationship between emotions and the symptoms clearer, plasmin which induced the serum complemental activation, was picked up. Plasminic activity was measured during the adrenaline test. The result showed that plasminic activity increased and returned to normal following the bodily response, i.e. the change of pulse rate, blood pressure, pulse wave and urinary catecholamine, to the adrenaline. In the animal experiment, the stimulation of the rats by light, buzzer and electric current, increased the plasma plasminic activity, and results showed a peculiar fluctuation of plasminic activity; in the chronic stress groups, this response being greater than that of the group without the chronic stress. From these findings, the emotional stress is considered to accelerate the plasminic activity through the autonomic nervous system, and to act as the trigger in HANE. The relation between plasminic activity and the hormonal feedback was examined, according to the results that urinary excretion of 17 OHCS reduced when plasma plasminic activity increased, and that the increased plasminic activity interfered with the hormonal feedback. Plasmin which acts on many substances, is activated easily by emotional stress, especially in allergic diseases.

This publication has 0 references indexed in Scilit: