Effect of Quality and Quantity of Dietary Fat and Dimethylhydrazine in Colon Carcinogenesis in Rats

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Abstract
The effect, quality, and quantity of dietary fat on colon tumor induction by DMH were studied in rats exposed to a given regimen for two generations prior to treatment with DMH. Animals fed a 20% corn oil or 20% lard and treated with DMH had a higher incidence of colonic tumors than did rats fed a 5% corn oil, 5% lard or Purina lab chow and treated similarly. The quality of fat had no major difference on the incidence of colonic tumors.