Stimulation of Immune Response in Hybrid Mice Following Rauscher Virus Infection

Publisher Website
Google Scholar
Abstract
The effect of Rauscher leukemia virus [RLV] injection on the splenic PFC [plaque forming cell] response to SRBC [sheep red blood cells] was measured in a mouse strain sensitive to the virus (SJL/J), 1 resistant to the virus (C57B1/10) and their F1 hybrid (SJL/JxC57B1/10)F1. A significant immunostimulation by the virus was seen. Immunostimulation was also seen in the resistant parent when the PFC response level was measured 12 days or later after RLV infection. The PFC response of the sensitive parent was nearly completely suppressed. Evaluation of the effect of RLV on the splenic masses of the 3 strains indicated a mild transient splenomegaly in the hybrid; a pronounced splenomegaly in the sensitive parent; and no effect on the resistant strain. The change in splenic PFC number in the hybrid following RLV infection may occur as a function partially independent of changes in the total splenic mass.

This publication has 0 references indexed in Scilit: