Synthesis and Properties of [11-Serine]α-Melanotropin
- 1 January 1977
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 358 (2) , 1475-1482
- https://doi.org/10.1515/bchm2.1977.358.2.1475
Abstract
[Ser11].alpha.-melanotropin was prepared and its melanotropic activity compared with that of .alpha.-melanotropin and several known analogues [in vitro on the skin of Rana pipiens and in vivo in R. esculenta and Xenopus laevis]. Full activity does not depend on the positive charge of 11-lysine in .alpha.-melanotropin but on the hydrophilic character of the amino group or a corresponding residue. A shift, or even more, a loss of such a group decreases the melanotropic activity.This publication has 2 references indexed in Scilit:
- 95. Zwei Synthesen des α-Melanotropins (α-MSH) mit Hilfe leicht entfernbarer Schutzgruppen)Helvetica Chimica Acta, 1963
- Ultraviolet Absorption Spectra of Proteins and Amino AcidsAdvances in Protein Chemistry, 1952