Laboratory Evaluation of a Sustained-Release Famphur Bolus Against Gulf Coast and Lone Star Ticks Feeding on Hereford Heifers12

Abstract
Fifty % famphur boluses orally administered to cannulated Hereford heifers weighing 180 kg were found to release an avg 304 mg/bolus/day over a 60-day period. Four–5 boluses were needed to provide a dosage of ca. 7 mg/kg/day. In 3 sequential experimental groups, treated and control heifers were challenged at 7–25, 26–45, and 46–64 days after treatment with the 3 feeding stages of the Gulf Coast tick, Amblyomma maculatum Koch, and the lone star tick, A. americanum (L.). Famphur boluses provided 100, 99, and 99% estimated cumulative control of A. maculatum and 71, 86, and 60% estimated cumulative control of A. americanum. respectively, for the 3 experimental groups. Clinical signs of organophosphate poisoning were not observed among treated heifers.

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