Immunological processes in malaria pathogenesis
Top Cited Papers
- 1 September 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 5 (9) , 722-735
- https://doi.org/10.1038/nri1686
Abstract
Malaria is possibly the most serious infectious disease of humans, infecting 5-10% of the world's population, with 300-600 million clinical cases and more than 2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial, but incomplete, protection against pathogen replication; however, these complex immunological reactions can contribute to disease and fatalities. So, appropriate regulation of immune responses to malaria lies at the heart of the host-parasite balance and has consequences for global public health. This Review article addresses the innate and adaptive immune mechanisms elicited during malaria that either cause or prevent disease and fatalities, and it considers the implications for vaccine design.Keywords
This publication has 118 references indexed in Scilit:
- Inhibition of Platelet Adherence to Brain Microvasculature Protects against SeverePlasmodium bergheiMalariaInfection and Immunity, 2003
- Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral MalariaInfection and Immunity, 2003
- Pathophysiology of Cerebral MalariaAnnals of the New York Academy of Sciences, 2003
- Malaria and anemiaCurrent Opinion in Hematology, 2003
- A role for Toll in autoimmunityNature Immunology, 2002
- Direct cell/cell contact with stimulated T lymphocytes induces the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cellsEuropean Journal of Immunology, 1996
- Glycosylphosphatidylinositol Toxin of Trypanosoma brucei Regulates IL-1α and TNF-α Expression in Macrophages by Protein Tyrosine Kinase-Mediated Signal TransductionBiochemical and Biophysical Research Communications, 1994
- Cerebral malaria: Mediators, mechanical obstruction or more?Parasitology Today, 1994
- Tumour necrosis factor-α and macrophages inPlasmodium berghei-induced cerebral malariaParasitology, 1993
- Cytotoxicity of human natural killer (NK) cell subsets for Plasmodium falciparum erythrocytic schizonts: stimulation by cytokines and inhibition by neomycinClinical and Experimental Immunology, 1991