Influences of compounds on metallothionein concentration in mouse tissues. I. Increase of hepatic metallothionein concentration by organic solvents and fatty acids.

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Abstract
Mice were injected with organic solvents and fatty acids, and the concentration of metallothionein in the mouse tissues was determined. The following results were obtained. 1. The metallothionein concentration in the liver increased by the injections of n-heptane, n-hexane and benzene. 2. The Zn-thionein concentration increased to 323 .+-. 44 .mu.g/g after the injection of n-heptane injection, and the acute cadmium toxicity was prevented by pre-injection of n-heptane. 3. The concentration of metallothionein in the mouse liver increased by the injections of oleic acid and linoleic acid. These results demonstrate that the concentration of metallothionein in the mouse liver increased by the organic solvents and fatty acids.

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