Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen
Open Access
- 1 February 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 20 (2) , 250-256
- https://doi.org/10.1359/jbmr.041004
Abstract
The pathway(s) by which disuse is transduced into locally mediated osteoclastic resorption remain unknown. We found that both acute disuse (in vivo) and direct hypoxia (in vitro) induced rapid upregu...Keywords
This publication has 49 references indexed in Scilit:
- Hypoxia is a major stimulator of osteoclast formation and bone resorptionJournal of Cellular Physiology, 2003
- Resistance to Unloading-Induced Three-Dimensional Bone Loss in Osteopontin-Deficient MiceJournal of Bone and Mineral Research, 2002
- Soluble osteopontin inhibits apoptosis of adherent endothelial cells deprived of growth factors*Journal of Cellular Biochemistry, 2002
- Parathyroid Hormone-induced Bone Resorption Does Not Occur in the Absence of OsteopontinPublished by Elsevier ,2001
- Spatial and temporal distribution of CD44 and osteopontin in fracture callusThe Journal of Bone and Joint Surgery. British volume, 1999
- Detection of Mouse Osteopontin by Western BlottingBiochemical and Biophysical Research Communications, 1998
- Signal Transduction of Mechanical Stimuli Is Dependent on Microfilament Integrity: Identification of Osteopontin as a Mechanically Induced Gene in OsteoblastsJournal of Bone and Mineral Research, 1997
- Pulsating Fluid Flow Increases Prostaglandin Production by Cultured Chicken Osteocytes—A Cytoskeleton-Dependent ProcessBiochemical and Biophysical Research Communications, 1996
- Changes in biological activity of bone cells in ovariectomized rats revealed by in situ hybridizationJournal of Bone and Mineral Research, 1996
- Studies of Skeletal Remodeling in Aging MenPublished by Wolters Kluwer Health ,1980