Glucose metabolism and rate constants in Alzheimer's disease examined with dynamic positron emission tomography scan
- 1 October 1989
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 80 (4) , 307-313
- https://doi.org/10.1111/j.1600-0404.1989.tb03884.x
Abstract
— Glucose metabolic rate constants in patients with Alzheimer's disease were analyzed using dynamic positron emission tomography with [18-F] fluoro-2-deoxyglucose (FDG). The cerebral metabolic rate of glucose (CMRG) was calculated using obtained rate constants, as well as the autoradiographic method. The half-life and distribution volume of FDG between the blood and the brain tissue were also calculated from obtained metabolic rate constants. The most severely affected metabolic step was the phosphorylation of glucose in the parietotemporal regions. The distribution volume of FDG showed no remarkable deviation from normal controls, while the half-life of FDG was found to be longer in the parietal and temporal regions. The CMRG from rate constants and that from the autoradiographic method showed no remarkable differences.Keywords
This publication has 20 references indexed in Scilit:
- Examination of Blood — Brain Barrier Permeability in Dementia of the Alzheimer Type with [68Ga]EDTA and Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1987
- Effect of Vascular Activity in the Determination of Rate Constants for the Uptake of 18F-Labeled 2-Fluoro-2-Deoxy-D-Glucose: Error Analysis and Normal Values in Older SubjectsJournal of Cerebral Blood Flow & Metabolism, 1986
- Tomographic Mapping of Kinetic Rate Constants in the Fluorodeoxyglucose Model Using Dynamic Positron Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1986
- Glucose Metabolic Rate Kinetic Model Parameter Determination in Humans: The Lumped Constants and Rate Constants for [18F]Fluorodeoxyglucose and [11C]DeoxyglucoseJournal of Cerebral Blood Flow & Metabolism, 1985
- Estimation of Local Cerebral Glucose Utilization by Positron Emission Tomography of [18F]2-Fluoro-2-Deoxy-D-Glucose: A Critical Appraisal of Optimization ProceduresJournal of Cerebral Blood Flow & Metabolism, 1985
- Regional Kinetic Constants and Cerebral Metabolic Rate for Glucose in Normal Human Volunteers Determined by Dynamic Positron Emission Tomography of [18F]-2-Fluoro-2-Deoxy-D-GlucoseJournal of Cerebral Blood Flow & Metabolism, 1984
- Alternative Approach to Single-Scan Estimation of Cerebral Glucose Metabolic Rate Using Glucose Analogs, with Particular Application to IschemiaJournal of Cerebral Blood Flow & Metabolism, 1984
- Computed Tomography and Positron Emission Transaxial Tomography Evaluations of Normal Aging and Alzheimer's DiseaseJournal of Cerebral Blood Flow & Metabolism, 1983
- Alzheimer's diseaseNeurology, 1983
- Effect of Ischemia on Quantification of Local Cerebral Glucose Metabolic Rate in ManJournal of Cerebral Blood Flow & Metabolism, 1981