Histamine gastric ulceration and its prevention by degraded carrageenan: the effect of aminoguanidine sulphate

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Abstract
Pretreatment of the guinea-pig with intravenous aminoguanidine sulphate, a drug believed to inhibit histaminase, changes the gastric ulcer response following a dose of histamine acid phosphate (2·5 mg/kg) which elicits a submaximal ulcer response, to that of a dose (5 mg/kg) which normally elicits a maximal gastric ulcer response. A reduction in the volume and acidity of secretion also occurs. Intraduodenal administration of degraded carrageenan prevents this action of aminoguanidine. Conversely, in the presence of aminoguanidine, carrageenan fails to protect against histamine ulceration.

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