Enhancement of R-Plasmid-Determined Resistance to Aminoglycoside Antibiotics by R-Plasmid Nitrofurantoin Resistance in Escherichia coli

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Abstract
Transfer of an R-plasmid, which confers nitrofurantoin resistance (by decreasing host strain nitrofurantoin reductase activity) to Escherichia coli K12 conferring R-plasmid aminoglycoside antibiotics resistance, increased the aminoglycoside resistance level several fold. An F′ (Lac+, leu+, thr+, pro+, Gal+Mal+) plasmid decreased the nitrofuran resistance level, annuled the increased aminoglycoside resistance and restored nitrofuran reductase activity in the transconjugants.