Wilms's Tumor in Three Children of a Woman with Congenital Hemihypertrophy

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Abstract
NONE of the pediatric neoplasms demonstrate more strikingly than Wilms's tumor the relation between teratogenesis and oncogenesis.1 Congenital anomalies more frequently found in children with this tumor include aniridia, visceral cytomegaly, hamartomas, genitourinary-tract anomalies and hemihypertrophy.2 3 4 5 Certain elements of these tumor-malformation syndromes may be distributed among several members of a family rather than being concentrated in a single one. Indeed, this may well be the explanation in the family described below, in which the mother had congenital hemihypertrophy, three of her children had Wilms's tumor, and a fourth had a urinary-tract anomaly.Case ReportsCase 1. The first of the . . .

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