Effect of 4-Hydroxypyrazolo [3, 4-d] pyrimidine on Uricase Activity

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Abstract
Oral administration of 4-hydroxypyrazolo[3,4-d]pyrimidine (H.P.P.) to various species of animals was previously found to exhibit sex differences in its blood level, excretion time and serum uric acid value. The effect of H.P.P. on uricase activity was examined in mice by applying various concentrations of H.P.P. to the homogenate. The 1st and 2nd fractions were prepared from mouse liver, and their uricase activity was measured. The sex difference in the decrease of serum uric acid and effective period after oral administration of H.P.P. were due, in part, to the difference in the degree of uricase activation by H.P.P. The difference in blood level and excretion time after administration of H.P.P. was discussed.

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