FORMATION OF CATECHOL-LIKE AND MONOPHENOLIC METABOLITES OF PROPRANOLOL BY RAT-LIVER 9000G SUPERNATANT

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 11-22
Abstract
The oxidation of the naphthalene ring system of propranolol by the rat liver 9000 g supernatant was studied by gas chromatography-mass spectrometry. Two dihydroxy metabolites, 1 of which possibly catechol-like, and 4 monophenols were identified based on the mass fragmentation pattern and retention times of their trimethylsilyl and d9-trimethylsilyl derivatives. These observations emphasize the complex oxidation pattern of this drug. All metabolites identified are proposed to be associated with significant biological activity.