Age Stability of Human Brain 5-HT Terminals Studied with [3H]Paroxetine Binding
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in Gerontology
- Vol. 38 (3) , 127-132
- https://doi.org/10.1159/000213319
Abstract
The effect of age on serotonin uptake sites labeled with [3H]pa-roxetine was studied in two sets of brains. The first set included 28 subjects (19 males and 9 females) between the ages 0 and 100 years. The cortex of cingulate gyrus and the amygdala were studied. No age-related changes in binding capacity (Bmax) or binding affinity (Kd) were noted. In the second set, the frontal cortex and hypothalamus from 22 subjects (18 males and 4 females) between 16 and 75 years were studied. No age-related changes in the binding were observed. The interval between death and freezing of the tissue did not influence the binding. Regarding the [3H]paroxetine binding as an indirect marker for 5-HT terminals, the data suggest a stability of 5-HT terminals with increasing age in the human brain.Keywords
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