Lack of Effect of 28 Days of Neuroleptic Treatment on Platelet Benzodiazepine Binding Sites in Schizophrenics
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 17 (3) , 121-123
- https://doi.org/10.1159/000118349
Abstract
Twenty-eight days of neuroleptic treatment of 11 schizophrenics aged 16–23 years did not affect the binding values of 3H-PK 11195 to platelets. This lack of effect was in contrast to reduced peripheral benzodiazepine binding sites (PBS) observed in platelets of schizophrenics medicated over 2 years. These results may indicate that neuroleptic-induced down-regulation of PBS is a time-dependent phenomenon.Keywords
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