The oxyallyl cation in synthesis: preparation of analogues of cocaine
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 1564-1568
- https://doi.org/10.1039/p19780001564
Abstract
An attempt has been made to establish the synthetic utility of cycloaddition reactions involving the oxyallyl cation [graphic omitted]. Reactions of this intermediate (R1,R3= alkyl; R2,R4= H; and M = Na) with furan and N-methylpyrrole were particularly facile, and have been used for the synthesis of a number of novel analogues of cocaine. Although some of the cycloaddition products have been reported by other workers, there has always been a paucity of experimental details. We provide herein full experimental details for our reactions, and also a tabular survey of methods used and results obtained.This publication has 0 references indexed in Scilit: