Moments of physiological transit time distributions and the time course of drug disposition in the body
- 1 November 1982
- journal article
- Published by Springer Nature in Journal of Mathematical Biology
- Vol. 15 (3) , 305-318
- https://doi.org/10.1007/bf00275690
Abstract
Characterizing the tissue distribution kinetics of drugs by physiological and physico-chemical parameters and using a circulatory model the time course of blood concentration after intravenous injection is predicted for linear pharmacokinetic systems. The interrelationships between the first three (zero to second) moments of the distribution functions of organ transfer times, circulation times and residence times of drug molecules in the body are described. Utilizing literature data the model is applied to the analysis of lidocain kinetics in humans.Keywords
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