Enzymatic Kinetic Resolution of [4](1,2)Ferrocenophane Derivatives

Publisher Website
Google Scholar
Abstract
The enol acetate of (±)-[4](1,2)ferrocenophan-1-one was enantioselectively hydrolyzed by using lipase PS to afford (+)-(R)-[4](1,2)ferrocenophan-1-one and (+)-(S)-1-acetoxy[4](1,2)ferrocenophan-1-ene. By using lipase PS or lipozyme, (±)-1-acetoxy[4](1,2)ferrocenophane was resolved into the (+)-(1R)-alcohol and the (−)-(1S)-acetate. The lipase-mediated transesterification and esterification of (±)-1-hydroxy[4](1,2)ferrocenophane led to the formation of the (+)-(1R)-ester and the (−)-(1S)-alcohol.