Antigenic differences between normal human albumin and a genetic variant

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Abstract
Agglutinating antisera were induced in rabbits against a purified genetic variant of human albumin and against normal albumin. These antisera had different specificities, as determined by inhibition experiments with the purified variant and normal albumin. Genetic variants of human albumin may differ antigenically from the normal protein. Antibodies against normal human albumin could possibly be induced following albumin administration to individuals homozygous for an albumin variant.