Inhibition of hemolysis by zinc and its reversal by L-histidine
- 1 March 1978
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 19 (3) , 1101-1103
- https://doi.org/10.1128/iai.19.3.1101-1103.1978
Abstract
Hemolysis [of rat and sheep erythrocytes] induced by staphylococcal .alpha.-toxin, staphylococcal .beta.-toxin, streptolysin O and streptolysin S was inhibited by Zn2+ by virtue of inhibition of an early step in events leading to lysis, presumably by preventing lysins from attaching to the plasma membrane. In hemolysis induced by Clostridium perfringens .alpha.-toxin and by perfringolysin O, a later step was inhibited by Zn. In hemolysis caused by saponin, lysolecithin and Triton X-100, hemoglobin was precipitated by Zn2+ as it was released from the erythrocyte. Inhibition by Zn was abolished by several amino acids of which L-histidine was the most effective.This publication has 5 references indexed in Scilit:
- Inhibition by zinc of hemolysis induced by bacterial and other cytolytic agentsInfection and Immunity, 1976
- Metal-Albumin-Amino Acid Interactions: Chemical and Physiological InterrelationshipsPublished by Springer Nature ,1974
- Quantitative studies of the avidity of naturally occurring substances for trace metals. 2. Amino-acids having three ionizing groupsBiochemical Journal, 1952
- Quantitative studies on the avidity of naturally occurring substances for trace metals. 1. Amino-acids having only two ionizing groupsBiochemical Journal, 1950