Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients

3 May 2000

journal article
Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section

Vol. 107 (5) , 603-607
https://doi.org/10.1007/s007020070081

Abstract

Inositol levels measured in postmortem brain of unipolar, bipolar and schizophrenic patients, suicide victims and normal controls showed no difference in scyllo-inositol levels in frontal or occipital cortex between any of the groups. We could not replicate previous reports of low myo-inositol levels in the frontal cortex of unipolar, bipolar and schizophrenic patients and suicide victims. There was no correlation between myo-inositol levels and estimated chlorpromazine equivalents in neuroleptic-treated subjects, and no effect of chronic haloperidol treatment on rat brain myo-inositol levels.

Keywords

SUICIDE VICTIMS.
NEUROLEPTIC TREATMENT
MYO-INOSITOL
BIPOLAR PATIENTS
SCHIZOPHRENIC PATIENTS
UNIPOLAR PATIENTS
POST-MORTEM BRAIN
SCYLLO-INOSITOL

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