X-chromosome inactivation: counting, choice and initiation
Top Cited Papers
- 1 January 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Genetics
- Vol. 2 (1) , 59-67
- https://doi.org/10.1038/35047580
Abstract
In many sexually dimorphic species, a mechanism is required to ensure equivalent levels of gene expression from the sex chromosomes. In mammals, such dosage compensation is achieved by X-chromosome inactivation, a process that presents a unique medley of biological puzzles: how to silence one but not the other X chromosome in the same nucleus; how to count the number of X's and keep only one active; how to choose which X chromosome is inactivated; and how to establish this silent state rapidly and efficiently during early development. The key to most of these puzzles lies in a unique locus, the X-inactivation centre and a remarkable RNA — Xist — that it encodes.Keywords
This publication has 70 references indexed in Scilit:
- X Inactivation in the Mouse Embryo Deficient for Dnmt1: Distinct Effect of Hypomethylation on Imprinted and Random X InactivationDevelopmental Biology, 2000
- Histone Macroh2a1.2 Relocates to the Inactive X Chromosome after Initiation and Propagation of X-InactivationThe Journal of cell biology, 1999
- Tsix, a gene antisense to Xist at the X-inactivation centreNature Genetics, 1999
- Developmentally Regulated Xist Promoter Switch Mediates Initiation of X InactivationCell, 1998
- X-CHROMOSOME INACTIVATION IN MAMMALSAnnual Review of Genetics, 1997
- Stabilization of Xist RNA Mediates Initiation of X Chromosome InactivationCell, 1997
- X Chromosome Inactivation Is Mediated by Xist RNA StabilizationCell, 1997
- X-Inactivation and Histone H4 Acetylation in Embryonic Stem CellsDevelopmental Biology, 1996
- Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist.Proceedings of the National Academy of Sciences, 1995
- SOME MILESTONES IN THE HISTORY OF X-CHROMOSOME INACTIVATIONAnnual Review of Genetics, 1992