Interaction of E1040 with cephalosporinase from Citrobacter freundii GN7391
Open Access
- 1 December 1989
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 33 (12) , 2157-2159
- https://doi.org/10.1128/aac.33.12.2157
Abstract
The interactions of E1040 with cephalosporinase from Citrobacter freundii, including affinity and hydrolysis, were studied in comparison with those of cefotaxime and ceftazidime. E1040 showed a higher stability at low drug concentrations and a much lower affinity for the enzyme than did cefotaxime or ceftazidime. These enzymological properties explain the high activity of E1040 against cephalosporinase-producing C. freundii.This publication has 9 references indexed in Scilit:
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