Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans
- 12 January 1998
- journal article
- Published by Wiley in Journal of Veterinary Medicine, Series B
- Vol. 45 (1-10) , 529-537
- https://doi.org/10.1111/j.1439-0450.1998.tb00824.x
Abstract
We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor‐alpha (TNF‐α) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF‐α are involved in apoptosis.Keywords
This publication has 21 references indexed in Scilit:
- Lipopolysaccharide induces apoptotic cell death of B memory cells and regulates B cell memory in antigen-nonspecific mannerFEMS Immunology & Medical Microbiology, 1996
- Coming to terms with death: apoptosis in cancer and immune developmentImmunology Today, 1994
- B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40Nature, 1993
- Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic miceNature, 1992
- A transgenic model of autoimmune hemolytic anemia.The Journal of Experimental Medicine, 1992
- Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigensNature, 1991
- Macrophage Activation by Leptospiral LipopolysaccharideZentralblatt für Bakteriologie, 1990
- Effects of Leptospiral Lipopolysaccharide on Rabbit PlateletsZentralblatt für Bakteriologie, 1989
- The autoantigen-binding B cell repertoires of normal and of chronically graft-versus-host-diseased mice.The Journal of Experimental Medicine, 1987
- Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationNature, 1980